GP100095: RPB1 CTD(1615-1621-Lys)-Tn(1619)

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Description

GP100095: RPB1 CTD(1615-1621-Lys)-Tn(1619)C46H73N11O18 1068. 1 DNA directed RNA polymerase II (Pol II) subunit RPB1 contains a Carboxy Terminal Domain (CTD) composed of up to 52 heptapeptide repeats (YSPTSPS) that are essential for polymerase activity. The CTD Nonconsensus Repeat, Tyr Ser Pro Thr Ser Pro Ser, is heavily modified by phosphorylation, glycosylation and proline isomerization. The CTD acts as a tether to bring into close proximity the machinery necessary to synthesize and process

UniProt position 541-549

Synthetic DTNB(GlcNAc) glycopepetide

3-Aminopropyl 6’-sialyl LacNAc

α-L-Rha-Et-N3

03 / / Losartan N1-β-D-Glucuronide / Losartan N1-Glucuronide

α-D-GalNAc-Bu-COOH

Neu5Gc-α-4MU

aa length 10) with Sialyl TF (Neu5Acα2-3Galβ1-3GalNAc) at Thr541

Radsterin-d6

41 / Synthetic glycopeptide

The sialic acid carboxyl is protected as a methyl ester to prevent side reactions during synthesis

68 / / 1-α-Hydroxy Vitamin D3-d6 / 1α-Hydroxycholecalciferol-d6