GA121030: Fmoc-Ser(Galβ(1-3)(GlcNAcβ(1-6))GalNAc-OH (Peracetate)

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Description

GA121030: Fmoc-Ser(Galβ(1-3)(GlcNAcβ(1-6))GalNAc-OH (Peracetate)C56H69N3O28 1232. 15 An Fmoc protected L serine building block carrying a branched Gal1 3[GlcNAc1 6]GalNAc trisaccharide, designed for solid phase peptide synthesis (SPPS) of glycopeptides. The N Fmoc group is removed under standard base conditions (piperidine) during chain elongation, while the free carboxylic acid is available for coupling to the growing resin bound peptide. The sugar hydroxyl groups are protected as acetate esters (peracetate),

This compound presents an A2 biantennary N-glycan capped with α2-6-linked sialic acid (disialo) on an Asn core

enabling sensitive

C13H26N2O6 / 306

GlcNAc β(1-4) GlcNAc-β-PNP

3-Azidopropyl α-D-Mannopyranoside

41 / A β-D-lactose ligand equipped with a thiol-functionalized linker through a short ethyl spacer

22 / An α-D-galactose ligand equipped with an azide-functionalized linker through a short ethyl spacer

Fmoc-L-Thr((Ac)3-Fuc-α-L)-OH

it is removed by hydrogenolysis or basic hydrolysis during global deprotection

Fmoc-Ser(beta-L-Rha)-OH (Peracetate)

/ Fmoc-Ser((Ac)3-Fuc-α-L)-OH / Fmoc-Ser(α-L-Fuc)-OH

α-L-Rha-Bu-CO2H