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Description

GP100083: MUC5AC(2449-2464)-Tn(2451)C71H118N18O30 1703. 8 Muc5AC (UniProt ID P98088) is a gel forming glycoprotein produced by the goblet cells in the tracheobronchial surface epithelium. MUC5AC Tn(3) is a synthetic 16 amino acid glycopeptide fragment and tandem repeat sequence of MUC5AC (Gly2449 Pro2464) where O glycosylation (GalNAc) is at amino acid Thr 3 (Thr2451 in protein). The C terminus is an amide. MUC5AC(2449 2464) Tn(2451) Mucin5; Synthetic MUC 5 (Tn) glycopeptide; MUC5AC

Arg8 is conjugated at N-terminal

C31H49D3O3 / 475

Terminal β-Gal residues are also a substrate for glycosyltransferases

UniProt position 137-156

6-tetra-O-acetyl-α-D-mannopyranosyl)-L-serine

Fmoc-L-Asn(Glc(Ac)4-β-D)-OH

The installed glycan is a cellobiose (Glcβ1-4Glc) disaccharide

/ β-D-GalNAc-Hexyl-Amine / β-D-GalNAc-Hex-NH2

C32H39NO9 / 581

α-L-Rha-Bu-CO2H

MUC5AC(2449-2464)-Tn(2451)

Fmoc-Thr(β-D-Cellibiose)-OH (Peracetate)